Automatic regulation of inspiratory oxygen concentration on the basis of pulse oximetry enables oxygen to be applied in accordance with guidelines. High O2 concentrations can lead to unexpected events. The spectrum ranges from inflammatory airway reactions, resorptive atelectasis and seizures to increased in-hospital mortality. Under high-flow oxygen therapy and ventilation, oxygen saturation must be closely monitored, and inspiratory oxygen concentration constantly adjusted to the individual therapeutic range. LEOCLAC uses integrated pulse oximetry to continuously adapt inspiratory oxygen concentration to the defined therapeutic range. Combinable with invasive or non-invasive ventilation and high-flow therapy, LEOCLAC continuously assesses pulse wave quality and detects any artifacts. Different sizes and models of SpO2 sensors are available for LEOCLAC. Heart rate, oxygen saturation and plethysmography curve can be monitored independently by LEOCLAC. An intelligent graph makes it easy to evaluate FiO2 regulation.